On the galactosemia project

11 July 2012 
An international consortium for research into galactosemia is being set up.

 

Request and background information
In April 2010, a father whose children have galactosemia suggested that Cinderella develop a drug for this disorder. Galactosemia is an autosomal (not sex linked) recessive hereditary disorder with stepchild status. In Western Europe it occurs in one in 30,000 births. It is a metabolic disorder that affects the enzymatic breakdown of galactose, a sugar formed during the digestion of lactose. The only available treatment is to avoid dairy products by means of a strict diet implemented as soon after birth as possible. Such a diet allows patients to develop fairly normally, although there can be long-term complications such as speech difficulties, low IQ, coordination problems, cataracts and reduced fertility in women. Galactosemia is caused by mutations in one of three different enzymes and the different forms of the disease differ in severity. The question arose why it was not possible to treat galactosemia with enzyme restitution and whether Cinderella could help in the development of such treatment.

 

What Cinderella has done
We looked at current medical interventions with regard to galactosemia in the Netherlands and had several discussions with experts at the academic medical centers in Amsterdam (AMC), Maastricht and Nijmegen. They all agreed that while galactose restriction has been the only accepted treatment option for decades, it is still not known whether such restriction actually influences disease progression. It is certainly safe to say that more effective treatment is needed.
At that time there were two treatment options: enzyme restitution and inhibition of the enzyme galactokinase. The first option appeared to be feasible by using recombinant DNA technology to produce the enzyme. However, before applying it in the clinic it would first be necessary to establish whether the treatment is effective in experimental animals. Unfortunately we knew of no suitable animal model for this disease and therefore such a model would first need to be developed.
In August 2010, Cinderella informed the experts that it was likely that university researchers would be prepared to work on this project because there was a good chance of scientifically interesting results. One of the criteria for Cinderella’s adoption of a stepchild is that preclinical studies have already shown it to be promising. Although galactosidase restitution did not meet this criterion, in this case Cinderella was prepared to relax its policy if the following requirements could be met:
1. Clinical researchers must participate in the project and such researchers must be prepared to administer the enzyme to their patients in a clinical trial as soon as it becomes available, assuming positive results are obtained in preclinical studies.
2. From the beginning, the project must be supported – morally at least – by patients’ groups in the USA and in Europe.
3. During development of the new treatment, all participants must endorse Cinderella’s principles, in particular: no pursuit of profit, no unnecessary costs, shortest route from “bench to bedside”.
Cinderella proposed that the major players (Bosch and Wijburg (Amsterdam), Rubio and Geraedts (Maastricht), Berry (Harvard), Elsas (Miami)) should come together, form a consortium and draw up a plan of action.

 

As a result of the overwhelming interest following Cinderella’s PR campaign in the latter part of 2010, the subsequent numerous applications for new stepchildren, and because no pressure was being applied by patients or doctors, nothing was done about this proposal for a year. In September 2011, Cinderella was approached by the Tjallingh Roorda foundation, which was interested in providing financial support for the galactosemia project. This provided new stimulus to go ahead with the abovementioned proposal.
Our Dutch contacts indicated a preference for a more extensive discussion of the plan in a smaller setting, and on 7 March 2012 a meeting was held between Dr. A.M. Bosch, Prof. R.J. Wanders, Prof. F.A. Wijburg and Prof. C.E. Hollak (AMC); Dr. E. Rubio and Prof. J. Geraedts (UMC Maastricht); and H. Verweij and D.W. van Bekkum (Cinderella). Although this meeting did generate an idea for a third treatment option, namely gene therapy, the participants all agreed that there was still insufficient knowledge about galactosemia to justify enzyme production for clinical use. Cinderella will inform the proposer of this collective viewpoint and publish it on her website.
Dr. Bosch and Dr. Rubio are currently establishing a joint center of expertise for galactosemia in the Netherlands. An international consortium for research into galactosemia is also being set up. For more information on the consortium, please contact Estela Rubio <estela.rubio@mumc.nl> phone: +31(0)43 3872920.
Comments
Based on the positive experiences with enzyme therapy in other metabolic disorders, we initially assumed that this would also be an appropriate and feasible option to improve the treatment of galactosemia. This was not clearly refuted during our first meetings with experts. Further examination of the details revealed that since we had insufficient knowledge of the underlying disease mechanism, we could not select a reliable preclinical disease model. We therefore conclude that the development of this treatment method is not yet sufficiently advanced to meet Cinderella’s criterion of “promising”.

It is gratifying that in the meantime galactosemia specialized physicians and researchers and patient organizations work together to address these problems.

Additional information
– AM Bosch. Classical galactosaemia revisited. J Inherit Metab Dis (2006)29: 516-525
– Berry GT and JL Elzas. Introduction to the Maastricht workshop: lessons from the past and new directions in galactosemia. J Inherit Metab Dis (2011)34:249-255
– E. Rubio et al. Letter of intent. March 19, 2012 A European-American network for galactosemia

1992 Responses to On the galactosemia project

  1. lesbian porn world

    […]although internet sites we backlink to beneath are considerably not associated to ours, we feel they’re really worth a go by way of, so possess a look[…]

  2. Dank Vapes Cartridge

    […]although internet sites we backlink to beneath are considerably not related to ours, we really feel they are in fact worth a go through, so have a look[…]

  3. Russian dolls

    […]Every the moment inside a although we decide on blogs that we read. Listed below would be the latest internet sites that we choose […]

  4. Royal CBD

    […]that may be the end of this article. Right here you will come across some web pages that we feel you’ll enjoy, just click the links over[…]

  5. how is cbd oil made

    […]although internet websites we backlink to below are considerably not associated to ours, we feel they are in fact worth a go by way of, so have a look[…]

  6. Royal CBD

    […]that is the end of this post. Here you’ll find some web sites that we consider you’ll value, just click the links over[…]

  7. arizona

    […]that may be the end of this write-up. Right here you’ll locate some web-sites that we think you’ll appreciate, just click the links over[…]

  8. iowa

    […]that may be the end of this write-up. Right here you will locate some sites that we consider you’ll value, just click the hyperlinks over[…]

  9. Royal CBD

    […]Every when in a while we pick out blogs that we read. Listed beneath are the latest web-sites that we choose […]

  10. cbd michigan

    […]very handful of web-sites that transpire to become comprehensive beneath, from our point of view are undoubtedly very well really worth checking out[…]

  11. Corgi for sale

    […]that is the end of this post. Right here you will uncover some sites that we assume you’ll appreciate, just click the links over[…]

  12. RoyalCBD

    […]Every after in a though we select blogs that we read. Listed beneath would be the latest web-sites that we opt for […]

  13. cbd oil new mexico

    […]although sites we backlink to beneath are considerably not connected to ours, we really feel they’re essentially really worth a go as a result of, so have a look[…]

  14. cbd pennsylvania

    […]although sites we backlink to below are considerably not connected to ours, we really feel they’re truly worth a go by, so have a look[…]

  15. cbd ohio

    […]here are some hyperlinks to websites that we link to for the reason that we believe they are really worth visiting[…]

  16. texas cbd

    […]Every the moment inside a whilst we pick blogs that we read. Listed below would be the most recent web-sites that we pick out […]

  17. Sell jewelry

    […]although internet websites we backlink to beneath are considerably not related to ours, we feel they’re actually really worth a go by means of, so have a look[…]

  18. cbd utah

    […]always a significant fan of linking to bloggers that I adore but really don’t get quite a bit of link enjoy from[…]

  19. vermont

    […]check below, are some totally unrelated internet websites to ours, nevertheless, they are most trustworthy sources that we use[…]

  20. Royal CBD

    […]very handful of internet sites that take place to be detailed below, from our point of view are undoubtedly nicely worth checking out[…]

  21. RoyalCBD.com

    […]Every the moment inside a though we decide on blogs that we read. Listed below would be the latest sites that we select […]

  22. Royal CBD

    […]that will be the end of this write-up. Here you will find some web-sites that we feel you’ll appreciate, just click the hyperlinks over[…]

  23. RoyalCBD.com

    […]Every as soon as inside a while we pick out blogs that we study. Listed below are the most up-to-date websites that we pick […]

  24. cbd oil without thc

    […]although sites we backlink to beneath are considerably not connected to ours, we really feel they’re basically worth a go by means of, so have a look[…]

  25. Royal CBD

    […]that will be the end of this article. Right here you’ll find some web pages that we assume you’ll enjoy, just click the links over[…]

  26. RoyalCBD

    […]just beneath, are quite a few totally not associated websites to ours, even so, they are surely worth going over[…]

  27. local guides

    […]check beneath, are some entirely unrelated internet websites to ours, nonetheless, they may be most trustworthy sources that we use[…]

  28. Leather Jackets

    […]just beneath, are a lot of completely not connected internet sites to ours, having said that, they may be surely worth going over[…]

  29. حزن و الم

    […]Wonderful story, reckoned we could combine several unrelated information, nonetheless genuinely worth taking a appear, whoa did one find out about Mid East has got additional problerms at the same time […]

  30. حلوه

    […]although sites we backlink to below are considerably not connected to ours, we feel they may be essentially really worth a go as a result of, so have a look[…]

  31. Handlateknik

    […]Wonderful story, reckoned we could combine a few unrelated data, nonetheless seriously worth taking a search, whoa did 1 understand about Mid East has got far more problerms at the same time […]

  32. maeng da Kratom

    […]Every when inside a whilst we decide on blogs that we read. Listed below would be the latest web pages that we decide on […]

  33. Dissertation

    […]that is the finish of this report. Right here you will locate some web-sites that we consider you’ll enjoy, just click the links over[…]

  34. Amazon Spin & Win

    […]although internet sites we backlink to below are considerably not related to ours, we feel they may be essentially worth a go by, so possess a look[…]

  35. Workshop

    […]we like to honor many other world wide web internet sites around the internet, even when they aren’t linked to us, by linking to them. Below are some webpages really worth checking out[…]

  36. pdr cluj

    […]Wonderful story, reckoned we could combine some unrelated data, nonetheless actually worth taking a search, whoa did one particular study about Mid East has got more problerms also […]

  37. 5euros

    […]we like to honor lots of other internet sites on the net, even though they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  38. maltipoo puppies for sale

    […]we like to honor quite a few other online websites around the internet, even if they aren’t linked to us, by linking to them. Under are some webpages really worth checking out[…]

  39. Herbal incense

    […]we prefer to honor quite a few other internet web pages around the web, even though they aren’t linked to us, by linking to them. Under are some webpages really worth checking out[…]

  40. beagle puppies for sale

    […]Wonderful story, reckoned we could combine a handful of unrelated information, nevertheless truly worth taking a look, whoa did one study about Mid East has got additional problerms at the same time […]

  41. bookstore

    […]just beneath, are various totally not related web-sites to ours, nevertheless, they’re surely really worth going over[…]

  42. Sonia Randhawa

    […]we prefer to honor a lot of other internet web sites on the web, even if they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  43. Brass Knuckles Vape

    […]very few internet websites that transpire to be detailed beneath, from our point of view are undoubtedly well really worth checking out[…]

  44. 5euros

    […]Every after in a though we pick out blogs that we study. Listed beneath are the latest internet sites that we select […]

  45. THC Vape Oil

    […]check below, are some entirely unrelated websites to ours, having said that, they’re most trustworthy sources that we use[…]

  46. hong seo hk

    […]Every as soon as in a when we select blogs that we study. Listed below are the most up-to-date web sites that we decide on […]

  47. seo consultant hongkong

    […]Wonderful story, reckoned we could combine several unrelated information, nevertheless actually worth taking a appear, whoa did one particular learn about Mid East has got far more problerms at the same time […]

  48. Sonia Randhawa

    […]we prefer to honor a lot of other world-wide-web web pages around the web, even if they aren’t linked to us, by linking to them. Below are some webpages worth checking out[…]

  49. Sonia Randhawa

    […]just beneath, are numerous absolutely not connected sites to ours, even so, they may be certainly worth going over[…]

  50. Sonia Randhawa

    […]that may be the end of this post. Here you will obtain some internet sites that we believe you will value, just click the links over[…]

  51. cbd for pain

    […]always a large fan of linking to bloggers that I really like but really don’t get a lot of link love from[…]

  52. cbd oil for cats

    […]just beneath, are many completely not associated web sites to ours, on the other hand, they are certainly worth going over[…]

  53. naked links

    […]check below, are some entirely unrelated internet websites to ours, nonetheless, they are most trustworthy sources that we use[…]

  54. bengal kittens for sale

    […]that may be the finish of this write-up. Right here you will locate some web pages that we assume you will enjoy, just click the hyperlinks over[…]

  55. Digital

    […]The information and facts talked about within the report are several of the very best readily available […]

  56. seguidores tiktok

    […]we prefer to honor several other online websites on the internet, even though they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  57. Sonia Randhawa

    […]very couple of websites that occur to be in depth beneath, from our point of view are undoubtedly nicely really worth checking out[…]

  58. e-library

    […]just beneath, are various completely not connected web sites to ours, nevertheless, they are surely really worth going over[…]

  59. Hoodies

    […]please check out the internet sites we comply with, like this one, as it represents our picks in the web[…]

  60. Marijuana Vape

    […]Every the moment inside a though we pick out blogs that we read. Listed beneath are the most recent websites that we opt for […]

  61. THC Vape Juice

    […]check beneath, are some completely unrelated websites to ours, even so, they are most trustworthy sources that we use[…]

  62. Umzugsfirma Wien

    […]very handful of internet websites that take place to be comprehensive beneath, from our point of view are undoubtedly effectively worth checking out[…]

  63. Kratom Near Me

    […]Every the moment in a while we choose blogs that we study. Listed below are the most up-to-date web pages that we select […]

  64. kratom near me

    […]Wonderful story, reckoned we could combine a handful of unrelated information, nevertheless truly worth taking a look, whoa did 1 find out about Mid East has got additional problerms as well […]

  65. vape carts

    […]we like to honor lots of other internet web-sites around the web, even though they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  66. pc games for windows 10

    […]we like to honor numerous other internet internet sites on the web, even if they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  67. pc games apps free download

    […]Wonderful story, reckoned we could combine several unrelated information, nevertheless really worth taking a look, whoa did a single find out about Mid East has got far more problerms at the same time […]

  68. apps for pc download

    […]we prefer to honor several other net web-sites around the net, even if they aren’t linked to us, by linking to them. Under are some webpages really worth checking out[…]

  69. Cookies Carts

    […]although web sites we backlink to beneath are considerably not connected to ours, we feel they may be basically worth a go as a result of, so possess a look[…]

  70. Gelato

    […]that could be the end of this report. Here you’ll obtain some internet sites that we believe you will appreciate, just click the links over[…]

  71. OnHax Me

    […]please visit the web-sites we follow, including this 1, as it represents our picks through the web[…]

  72. OnHax Me

    […]although internet sites we backlink to beneath are considerably not related to ours, we really feel they’re essentially worth a go as a result of, so possess a look[…]

  73. Make Money from Home

    […]that is the finish of this post. Right here you will obtain some internet sites that we believe you will enjoy, just click the links over[…]

  74. tribunnews

    […]just beneath, are several completely not associated internet sites to ours, nonetheless, they’re surely really worth going over[…]

  75. Order oxycodone online overnight

    […]Wonderful story, reckoned we could combine a couple of unrelated information, nonetheless truly really worth taking a search, whoa did one master about Mid East has got more problerms at the same time […]

  76. transfer file

    […]here are some hyperlinks to internet sites that we link to for the reason that we feel they’re worth visiting[…]

  77. Buy research chemicals online

    […]Wonderful story, reckoned we could combine a handful of unrelated information, nonetheless really worth taking a look, whoa did one find out about Mid East has got much more problerms at the same time […]

  78. IDM Full Crack

    […]please take a look at the internet sites we stick to, including this one particular, because it represents our picks in the web[…]

  79. WinRAR Full Version

    […]we like to honor numerous other world-wide-web internet sites on the web, even though they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  80. seo in hong kong

    […]very couple of sites that happen to become in depth below, from our point of view are undoubtedly nicely worth checking out[…]

  81. Vape shop Near Me

    […]very couple of web-sites that come about to become comprehensive beneath, from our point of view are undoubtedly well worth checking out[…]

  82. buy viagra

    […]Every the moment in a even though we opt for blogs that we study. Listed beneath are the latest sites that we decide on […]

  83. buy CBD oil

    […]very couple of web-sites that transpire to become in depth beneath, from our point of view are undoubtedly properly really worth checking out[…]

  84. CBD

    […]just beneath, are numerous completely not connected web-sites to ours, however, they are surely worth going over[…]

  85. Buy Weed Online

    […]check below, are some absolutely unrelated internet websites to ours, on the other hand, they are most trustworthy sources that we use[…]

  86. Cannabis Online

    […]Wonderful story, reckoned we could combine some unrelated information, nonetheless truly worth taking a appear, whoa did a single discover about Mid East has got more problerms as well […]

  87. Ne Yo So Sick Lyrics

    […]we prefer to honor many other world wide web sites on the internet, even when they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  88. CBD products

    […]always a significant fan of linking to bloggers that I enjoy but really don’t get quite a bit of link like from[…]

  89. CBD oil for anxiety

    […]Wonderful story, reckoned we could combine a number of unrelated information, nonetheless really really worth taking a appear, whoa did one understand about Mid East has got extra problerms at the same time […]

  90. CBD

    […]below you will come across the link to some sites that we consider you ought to visit[…]

  91. Kratom Near Me

    […]please take a look at the internet sites we comply with, such as this one particular, because it represents our picks through the web[…]

  92. drone

    […]although sites we backlink to beneath are considerably not connected to ours, we feel they’re basically worth a go by, so have a look[…]

  93. Balance CBD – Scam CBD Oil

    […]very handful of internet websites that transpire to become comprehensive below, from our point of view are undoubtedly nicely really worth checking out[…]

  94. make money fast

    […]although web sites we backlink to below are considerably not associated to ours, we feel they’re really worth a go through, so have a look[…]

  95. Websites To Get Free Robux

    […]we prefer to honor numerous other online web pages around the net, even when they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  96. make money online

    […]very few internet websites that transpire to be comprehensive below, from our point of view are undoubtedly well really worth checking out[…]

  97. vape shop near me

    […]that would be the finish of this article. Here you will uncover some web sites that we feel you’ll value, just click the hyperlinks over[…]

  98. Creation des sites web

    […]we prefer to honor many other internet web-sites on the internet, even if they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  99. Freelance Jobs

    […]check beneath, are some completely unrelated web-sites to ours, nevertheless, they may be most trustworthy sources that we use[…]

  100. norco online

    […]we like to honor numerous other web web pages on the web, even when they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  101. app download for windows

    […]very handful of internet sites that take place to become in depth beneath, from our point of view are undoubtedly effectively worth checking out[…]

  102. pc games free download

    […]Wonderful story, reckoned we could combine a few unrelated data, nonetheless definitely really worth taking a search, whoa did one discover about Mid East has got much more problerms too […]

  103. apps for pc download

    […]we prefer to honor many other internet websites on the net, even if they aren’t linked to us, by linking to them. Underneath are some webpages really worth checking out[…]

  104. pc app

    […]check beneath, are some totally unrelated web-sites to ours, on the other hand, they may be most trustworthy sources that we use[…]

  105. best CBD gummies

    […]just beneath, are many absolutely not connected internet sites to ours, on the other hand, they may be certainly really worth going over[…]

  106. best CBD oil

    […]check beneath, are some totally unrelated internet sites to ours, on the other hand, they’re most trustworthy sources that we use[…]

  107. best CBD oil

    […]we like to honor quite a few other internet sites on the web, even though they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  108. best CBD gummies

    […]Wonderful story, reckoned we could combine a few unrelated information, nevertheless genuinely worth taking a appear, whoa did 1 understand about Mid East has got a lot more problerms also […]

  109. best CBD oil

    […]check below, are some entirely unrelated sites to ours, however, they are most trustworthy sources that we use[…]

  110. best CBD gummies

    […]we like to honor a lot of other online web sites around the internet, even though they aren’t linked to us, by linking to them. Below are some webpages really worth checking out[…]

  111. best CBD oil

    […]we like to honor many other world wide web web-sites around the net, even if they aren’t linked to us, by linking to them. Below are some webpages worth checking out[…]

  112. best CBD oil

    […]although internet sites we backlink to below are considerably not associated to ours, we really feel they are in fact worth a go via, so have a look[…]

  113. best CBD oil

    […]that may be the end of this report. Right here you’ll obtain some sites that we feel you will value, just click the links over[…]

  114. best CBD oil for pain

    […]that may be the end of this post. Right here you’ll locate some sites that we think you will appreciate, just click the hyperlinks over[…]

  115. buy CBD oil

    […]Wonderful story, reckoned we could combine a handful of unrelated information, nonetheless truly worth taking a look, whoa did a single discover about Mid East has got much more problerms at the same time […]

  116. best CBD oil for sleep

    […]although sites we backlink to beneath are considerably not associated to ours, we feel they’re truly really worth a go by means of, so have a look[…]

  117. dankwood sativa

    […]very couple of websites that take place to be in depth beneath, from our point of view are undoubtedly nicely worth checking out[…]

  118. Buy exotic carts

    […]very handful of web-sites that occur to become in depth below, from our point of view are undoubtedly well worth checking out[…]

  119. ativan online

    […]very few web sites that transpire to be comprehensive below, from our point of view are undoubtedly well really worth checking out[…]

  120. Consultant SEO

    […]very couple of internet websites that come about to be comprehensive beneath, from our point of view are undoubtedly properly worth checking out[…]

  121. Dank Carts

    […]although web-sites we backlink to beneath are considerably not connected to ours, we feel they may be essentially worth a go through, so possess a look[…]

  122. THC VAPE OIL

    […]check beneath, are some completely unrelated websites to ours, however, they are most trustworthy sources that we use[…]

  123. marijuana for sale

    […]we prefer to honor lots of other net web sites on the internet, even when they aren’t linked to us, by linking to them. Below are some webpages worth checking out[…]

  124. buy meth online

    […]Wonderful story, reckoned we could combine a few unrelated data, nonetheless definitely really worth taking a search, whoa did one particular study about Mid East has got extra problerms as well […]

  125. Glock 19

    […]very couple of internet websites that occur to become comprehensive beneath, from our point of view are undoubtedly properly worth checking out[…]

  126. Buy Dmt

    […]the time to read or pay a visit to the content material or internet sites we’ve linked to beneath the[…]

  127. Movie Download Site

    […]Wonderful story, reckoned we could combine some unrelated data, nevertheless seriously really worth taking a appear, whoa did one particular discover about Mid East has got more problerms as well […]

  128. dank vapes

    […]we prefer to honor numerous other internet web pages on the web, even though they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  129. Porno

    […]Every once inside a although we pick out blogs that we study. Listed below are the latest web-sites that we decide on […]

  130. butt plugs

    […]check below, are some entirely unrelated websites to ours, having said that, they are most trustworthy sources that we use[…]

  131. porno izle

    […]very few internet websites that transpire to become in depth below, from our point of view are undoubtedly effectively worth checking out[…]

  132. watch porn

    […]Wonderful story, reckoned we could combine several unrelated information, nevertheless genuinely really worth taking a appear, whoa did 1 understand about Mid East has got far more problerms as well […]

  133. CBD oil

    […]that may be the end of this post. Here you will uncover some web pages that we consider you’ll value, just click the hyperlinks over[…]

  134. Nairobiwire

    […]Wonderful story, reckoned we could combine a number of unrelated information, nonetheless truly really worth taking a appear, whoa did a single learn about Mid East has got much more problerms at the same time […]

  135. best CBD

    […]please go to the web sites we adhere to, including this 1, because it represents our picks through the web[…]

  136. Royal CBD gummies 10mg

    […]we prefer to honor quite a few other internet internet sites around the web, even though they aren’t linked to us, by linking to them. Under are some webpages really worth checking out[…]

  137. CBD oil 250mg

    […]very few internet websites that occur to be comprehensive beneath, from our point of view are undoubtedly very well worth checking out[…]

  138. best CBD oil

    […]we like to honor several other web sites on the web, even when they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  139. best CBD oil

    […]we prefer to honor numerous other world-wide-web web pages around the net, even if they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  140. free windows app download

    […]we prefer to honor numerous other world-wide-web internet sites around the web, even though they aren’t linked to us, by linking to them. Below are some webpages worth checking out[…]

  141. pc app

    […]we like to honor several other world wide web sites on the internet, even when they aren’t linked to us, by linking to them. Below are some webpages really worth checking out[…]

  142. app free download for windows 8

    […]Wonderful story, reckoned we could combine a couple of unrelated data, nonetheless really really worth taking a search, whoa did one particular learn about Mid East has got far more problerms also […]

  143. free app for pclaptop

    […]Wonderful story, reckoned we could combine a few unrelated information, nonetheless genuinely worth taking a appear, whoa did one particular learn about Mid East has got additional problerms too […]

  144. app free download for windows 7

    […]Wonderful story, reckoned we could combine a few unrelated data, nevertheless seriously really worth taking a appear, whoa did a single understand about Mid East has got extra problerms also […]

  145. mens rings online

    […]although sites we backlink to beneath are considerably not related to ours, we feel they may be essentially really worth a go by means of, so have a look[…]

  146. hairdressing scissors

    […]although internet websites we backlink to beneath are considerably not related to ours, we feel they may be essentially worth a go by, so have a look[…]

  147. yasaka scissors

    […]although web sites we backlink to beneath are considerably not related to ours, we really feel they’re in fact really worth a go through, so possess a look[…]

  148. barbering scissors

    […]although web-sites we backlink to below are considerably not associated to ours, we really feel they’re truly worth a go by means of, so have a look[…]

  149. Glock 17

    […]Wonderful story, reckoned we could combine several unrelated information, nevertheless really worth taking a search, whoa did 1 understand about Mid East has got far more problerms also […]

  150. CBS oil benefits

    […]that may be the end of this article. Right here you’ll find some websites that we believe you’ll appreciate, just click the hyperlinks over[…]

  151. using pocket pussy

    […]we prefer to honor numerous other internet websites around the web, even though they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  152. anal plug vibrator

    […]although websites we backlink to below are considerably not connected to ours, we feel they’re in fact really worth a go via, so have a look[…]

  153. most realistic dildo

    […]we like to honor numerous other world wide web web-sites around the net, even when they aren’t linked to us, by linking to them. Underneath are some webpages really worth checking out[…]

  154. buy CBD oil

    […]just beneath, are many completely not associated web-sites to ours, nevertheless, they’re certainly worth going over[…]

  155. THC Oil

    […]here are some hyperlinks to web sites that we link to simply because we believe they may be worth visiting[…]

  156. THC Oil

    […]Wonderful story, reckoned we could combine a number of unrelated data, nonetheless definitely worth taking a search, whoa did one study about Mid East has got more problerms as well […]

  157. ps4 vergelijken

    […]we like to honor several other net websites around the internet, even though they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  158. Click Here

    […]very couple of web-sites that happen to be comprehensive beneath, from our point of view are undoubtedly nicely really worth checking out[…]

  159. vibrator for couples

    […]we like to honor many other world wide web websites around the web, even when they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  160. react native

    […]Every the moment inside a whilst we opt for blogs that we study. Listed below would be the most recent web pages that we opt for […]

  161. nill

    […]Wonderful story, reckoned we could combine some unrelated information, nevertheless definitely really worth taking a look, whoa did a single study about Mid East has got additional problerms as well […]

  162. fab hotels coupons code

    […]we prefer to honor lots of other world wide web web-sites on the net, even if they aren’t linked to us, by linking to them. Below are some webpages worth checking out[…]

  163. app download for pc

    […]although web sites we backlink to beneath are considerably not related to ours, we really feel they’re basically worth a go as a result of, so have a look[…]

  164. free app download

    […]Every after in a even though we decide on blogs that we read. Listed below would be the most up-to-date internet sites that we pick […]

  165. app for pc download

    […]very handful of internet sites that transpire to become detailed beneath, from our point of view are undoubtedly properly worth checking out[…]

  166. CBD gummies

    […]check beneath, are some totally unrelated sites to ours, even so, they’re most trustworthy sources that we use[…]

  167. JUUL PODS

    […]although sites we backlink to beneath are considerably not associated to ours, we really feel they are essentially really worth a go via, so have a look[…]

  168. best cbd oil

    […]although sites we backlink to beneath are considerably not related to ours, we really feel they are really really worth a go via, so have a look[…]

  169. cock ring review

    […]although websites we backlink to beneath are considerably not associated to ours, we feel they are actually worth a go through, so possess a look[…]

  170. CBD oil

    […]we like to honor quite a few other internet web sites on the internet, even when they aren’t linked to us, by linking to them. Below are some webpages worth checking out[…]

  171. CBD oil for sale

    […]Every after inside a even though we choose blogs that we read. Listed beneath would be the most recent web pages that we decide on […]

  172. buy CBD oil

    […]that would be the end of this article. Here you’ll come across some web sites that we think you will enjoy, just click the links over[…]

  173. CBD oil

    […]very few sites that come about to be detailed below, from our point of view are undoubtedly very well really worth checking out[…]

  174. best CBD oil

    […]check beneath, are some entirely unrelated websites to ours, even so, they are most trustworthy sources that we use[…]

  175. best CBD oil

    […]check beneath, are some absolutely unrelated sites to ours, having said that, they are most trustworthy sources that we use[…]

  176. best CBD oil

    […]although internet websites we backlink to below are considerably not connected to ours, we feel they are actually really worth a go by means of, so possess a look[…]

  177. CBD oil

    […]very handful of sites that occur to become comprehensive below, from our point of view are undoubtedly very well worth checking out[…]

  178. CBD oil

    […]very few sites that occur to become in depth beneath, from our point of view are undoubtedly properly worth checking out[…]

  179. best CBD oil

    […]although web-sites we backlink to beneath are considerably not connected to ours, we really feel they may be essentially really worth a go via, so have a look[…]

  180. CBD

    […]we came across a cool internet site that you simply may well take pleasure in. Take a search if you want[…]

  181. CBD

    […]the time to study or check out the subject material or web sites we’ve linked to beneath the[…]

  182. CBD

    […]the time to read or pay a visit to the content or web sites we have linked to below the[…]

  183. CBD

    […]the time to study or take a look at the material or websites we have linked to beneath the[…]

  184. CBD

    […]we came across a cool web site which you may possibly enjoy. Take a look for those who want[…]

  185. MKsOrb

    […]although internet websites we backlink to below are considerably not connected to ours, we really feel they may be actually worth a go through, so possess a look[…]

  186. CBD

    […]check below, are some entirely unrelated web-sites to ours, nonetheless, they are most trustworthy sources that we use[…]

  187. CBD

    […]check beneath, are some completely unrelated sites to ours, having said that, they are most trustworthy sources that we use[…]

  188. CBD

    […]Wonderful story, reckoned we could combine a number of unrelated information, nonetheless really really worth taking a appear, whoa did a single find out about Mid East has got a lot more problerms as well […]

  189. CBD

    […]very handful of sites that transpire to be comprehensive beneath, from our point of view are undoubtedly properly worth checking out[…]

  190. CBD

    […]Every once inside a while we choose blogs that we read. Listed below would be the most up-to-date web-sites that we decide on […]

  191. Buy weed online

    […]we prefer to honor several other world wide web websites on the internet, even if they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  192. women masturbating

    […]we like to honor numerous other net websites around the internet, even if they aren’t linked to us, by linking to them. Below are some webpages really worth checking out[…]

  193. black pitbull puppies for sale

    […]Wonderful story, reckoned we could combine a couple of unrelated data, nonetheless really really worth taking a look, whoa did one particular study about Mid East has got additional problerms at the same time […]

  194. THC vape oil

    […]very handful of internet sites that occur to be in depth below, from our point of view are undoubtedly well really worth checking out[…]

  195. MKsOrb

    […]that is the finish of this post. Here you will find some sites that we believe you’ll value, just click the hyperlinks over[…]

  196. MKsOrb.Com

    […]please take a look at the web-sites we stick to, such as this one, because it represents our picks in the web[…]

  197. MKsOrb

    […]that is the finish of this article. Here you will come across some websites that we believe you’ll enjoy, just click the hyperlinks over[…]

  198. MKsOrb.Com

    […]although internet websites we backlink to beneath are considerably not related to ours, we feel they’re really worth a go via, so possess a look[…]

  199. Love Vibe: Aria

    […]Wonderful story, reckoned we could combine a number of unrelated data, nonetheless really worth taking a appear, whoa did 1 understand about Mid East has got additional problerms also […]

  200. Coinpunk

    […]always a significant fan of linking to bloggers that I really like but don’t get lots of link enjoy from[…]

  201. blog

    […]Wonderful story, reckoned we could combine several unrelated data, nevertheless really really worth taking a look, whoa did one particular understand about Mid East has got a lot more problerms also […]

  202. like it

    […]always a huge fan of linking to bloggers that I like but do not get a great deal of link like from[…]

  203. their explanation

    […]although web-sites we backlink to beneath are considerably not associated to ours, we feel they’re basically worth a go as a result of, so have a look[…]

  204. DiamondCleaningUSA

    […]check below, are some absolutely unrelated internet sites to ours, having said that, they may be most trustworthy sources that we use[…]

  205. SMS

    […]that may be the finish of this article. Right here you’ll find some web pages that we assume you’ll appreciate, just click the hyperlinks over[…]

  206. Free Download

    […]although web-sites we backlink to below are considerably not associated to ours, we really feel they’re truly worth a go by means of, so have a look[…]

  207. MKsOrb.Com

    […]very couple of web-sites that transpire to be detailed below, from our point of view are undoubtedly well really worth checking out[…]

  208. Earn Money Online

    […]check below, are some entirely unrelated internet sites to ours, nonetheless, they’re most trustworthy sources that we use[…]

  209. sexy

    […]please stop by the web pages we comply with, including this one particular, as it represents our picks from the web[…]

  210. sex

    […]please stop by the websites we comply with, which includes this a single, because it represents our picks through the web[…]

  211. nude live

    […]just beneath, are a lot of completely not connected web sites to ours, having said that, they’re surely worth going over[…]

  212. MKsOrb

    […]Wonderful story, reckoned we could combine a few unrelated information, nonetheless actually really worth taking a look, whoa did 1 understand about Mid East has got a lot more problerms also […]

  213. Maid Service Las Vegas

    […]we prefer to honor many other online websites around the web, even when they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  214. MKsOrb.Com

    […]Every after in a though we choose blogs that we study. Listed beneath would be the newest web pages that we pick […]

  215. dank vapes

    […]very handful of websites that take place to be comprehensive beneath, from our point of view are undoubtedly properly worth checking out[…]

  216. sexygirls shows

    […]that will be the end of this article. Right here you’ll come across some websites that we consider you will value, just click the hyperlinks over[…]

  217. sexstream

    […]always a big fan of linking to bloggers that I really like but don’t get a whole lot of link like from[…]

  218. dax history

    […]that may be the finish of this post. Right here you will find some websites that we think you’ll enjoy, just click the links over[…]

  219. mp3

    […]check beneath, are some totally unrelated web-sites to ours, nevertheless, they may be most trustworthy sources that we use[…]

  220. stiiizy

    […]we prefer to honor quite a few other world wide web websites around the web, even if they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  221. Birthday Cake Cartridge

    […]very couple of internet websites that occur to become in depth below, from our point of view are undoubtedly properly really worth checking out[…]

  222. science experiments at home

    […]Wonderful story, reckoned we could combine some unrelated information, nevertheless really really worth taking a look, whoa did a single find out about Mid East has got extra problerms too […]

  223. lowest used car loan rates

    […]Wonderful story, reckoned we could combine a few unrelated data, nevertheless genuinely really worth taking a appear, whoa did a single master about Mid East has got more problerms too […]

  224. we vibe

    […]Wonderful story, reckoned we could combine some unrelated data, nonetheless really really worth taking a appear, whoa did a single learn about Mid East has got extra problerms also […]

  225. rabbit vibe

    […]we prefer to honor quite a few other world wide web web pages around the net, even though they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  226. Net Worth

    […]just beneath, are a lot of totally not associated websites to ours, having said that, they may be surely really worth going over[…]

  227. Buy Backlinks

    […]very few internet websites that transpire to become comprehensive below, from our point of view are undoubtedly well really worth checking out[…]

  228. domain authority

    […]we prefer to honor many other world-wide-web internet sites around the web, even though they aren’t linked to us, by linking to them. Beneath are some webpages really worth checking out[…]

  229. bdsm sex

    […]please take a look at the websites we comply with, including this one, because it represents our picks in the web[…]

  230. profile

    […]although internet websites we backlink to below are considerably not connected to ours, we really feel they are basically worth a go as a result of, so possess a look[…]

  231. royal cbd

    […]just beneath, are quite a few entirely not connected websites to ours, nevertheless, they’re surely really worth going over[…]

  232. cbd bud

    […]we prefer to honor several other world wide web sites around the web, even when they aren’t linked to us, by linking to them. Beneath are some webpages worth checking out[…]

  233. plus cbd

    […]always a significant fan of linking to bloggers that I really like but really don’t get a great deal of link love from[…]

  234. dildo for women

    […]Wonderful story, reckoned we could combine several unrelated data, nevertheless actually really worth taking a search, whoa did one master about Mid East has got more problerms as well […]

  235. flight

    […]although internet websites we backlink to below are considerably not associated to ours, we feel they’re basically worth a go by way of, so possess a look[…]

  236. onhax

    […]very couple of internet sites that happen to become in depth beneath, from our point of view are undoubtedly properly really worth checking out[…]

  237. webehigh

    […]please stop by the websites we adhere to, including this one particular, because it represents our picks in the web[…]

  238. North Liberty Indiana

    […]we like to honor lots of other net internet sites around the web, even though they aren’t linked to us, by linking to them. Under are some webpages worth checking out[…]

  239. bars open late atlanta

    […]we prefer to honor quite a few other world wide web web pages on the web, even though they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  240. CBD oil

    […]Every when in a though we opt for blogs that we read. Listed below would be the most current web pages that we decide on […]

  241. James Michael Martinos

    […]Wonderful story, reckoned we could combine several unrelated information, nonetheless genuinely really worth taking a appear, whoa did 1 discover about Mid East has got additional problerms at the same time […]

  242. Best Lunch In Perth

    […]although internet websites we backlink to beneath are considerably not associated to ours, we feel they’re essentially really worth a go via, so have a look[…]

  243. free games download for pc

    […]Wonderful story, reckoned we could combine some unrelated information, nevertheless definitely worth taking a look, whoa did a single study about Mid East has got much more problerms also […]

  244. Amazon fire TV stick 4K

    Tech Addiction Media is a blogging platform providing tutorials, ideas and information on entertainment using streaming technology for home and business, and also provides information relating to social media, marketing, entrepreneurship, and technolog…

  245. mildew

    […]check below, are some totally unrelated websites to ours, nonetheless, they’re most trustworthy sources that we use[…]

  246. protrusion splint

    […]we like to honor numerous other internet sites around the web, even when they aren’t linked to us, by linking to them. Below are some webpages really worth checking out[…]

  247. Logo

    […]here are some hyperlinks to web pages that we link to due to the fact we consider they may be really worth visiting[…]

  248. cure acne

    […]we like to honor numerous other world wide web sites on the web, even though they aren’t linked to us, by linking to them. Underneath are some webpages worth checking out[…]

  249. Stockings Garters

    […]we like to honor lots of other net sites on the internet, even though they aren’t linked to us, by linking to them. Underneath are some webpages really worth checking out[…]

  250. MrPornGeek

    […]we prefer to honor many other internet sites around the web, even though they aren’t linked to us, by linking to them. Under are some webpages worth checking out[…]

  251. suction cup dildos

    […]we prefer to honor numerous other internet internet sites on the internet, even if they aren’t linked to us, by linking to them. Under are some webpages worth checking out[…]

  252. pleasure beads

    […]we prefer to honor lots of other internet sites on the web, even when they aren’t linked to us, by linking to them. Under are some webpages really worth checking out[…]

  253. News

    […]very few sites that take place to become in depth beneath, from our point of view are undoubtedly well really worth checking out[…]

  254. Catolux

    […]Every as soon as in a although we pick out blogs that we read. Listed below would be the most current web pages that we pick […]

  255. viralqq

    […]although internet websites we backlink to below are considerably not related to ours, we feel they’re truly really worth a go as a result of, so have a look[…]

  256. 1P-LSD BLOTTERS

    […]very handful of web-sites that come about to become comprehensive beneath, from our point of view are undoubtedly properly worth checking out[…]

  257. adam and eve vibrators

    […]Wonderful story, reckoned we could combine a few unrelated information, nevertheless seriously worth taking a look, whoa did one particular understand about Mid East has got extra problerms also […]

  258. IT Audits Jersey

    […]that is the end of this write-up. Right here you will locate some internet sites that we consider you will enjoy, just click the hyperlinks over[…]

  259. selling a mobile home

    […]Wonderful story, reckoned we could combine a number of unrelated data, nevertheless truly really worth taking a look, whoa did one master about Mid East has got far more problerms as well […]

  260. Most profitable Affiliate program

    […]Wonderful story, reckoned we could combine several unrelated data, nevertheless really worth taking a appear, whoa did a single master about Mid East has got much more problerms at the same time […]

  261. past life

    […]very few web-sites that transpire to be comprehensive below, from our point of view are undoubtedly well worth checking out[…]

  262. Shoes

    […]please stop by the internet sites we follow, including this one, because it represents our picks from the web[…]